Article
Recovery of known T-cell epitopes by computational scanning of a viral genome.
Journal of computer-aided molecular design - 1 Apr 2002
Logean Antoine, Rognan Didier
Abstract excerpt
A new computational method (EpiDock) is proposed for predicting peptide binding to class I MHC proteins, from the amino acid sequence of any protein of immunological interest. Starting from the primary structure of the target protein, individual three-dimensional structures of all possible MHC-peptide (8-, 9- and 10-mers) complexes are obtained by homology modelling. A free energy scoring function (Fresno) is...
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