Article
Isolation and characterisation of nuclear mutants with enhanced mitochondrial mutability in the fission yeast Schizosaccharomyces pombe.
Microbiological research - 1 Jan 2002
Massardo Domenica Rita, Del Giudice Luigi, Del Giudice Angelica, Wolf Klaus
Abstract excerpt
In this paper we report the isolation and preliminary characterisation of nuclear mutants with increased mitochondrial mutability in fission yeast. Screening of about 2000 clones after nitrosoguanidine mutagenesis led to the isolation of ten mutator mutants. For one of them (mut-1) we show that the mutation is chromosomally encoded. The activity of the mutator is restricted to the mitochondrial genome, since it...
Topics
- Cell Nucleus
- Cytochrome b Group
- DNA, Mitochondrial
- Diuron
- Drug Resistance, Fungal
- Mutation
- Schizosaccharomyces