Complete absence of mitochondrial DNA in the petite-negative yeast Schizosaccharomyces pombe leads to resistance towards the alkaloid lycorine.

doi:10.1007/BF00712972

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Article

Complete absence of mitochondrial DNA in the petite-negative yeast Schizosaccharomyces pombe leads to resistance towards the alkaloid lycorine.

Current genetics - 1 Jan 1994

Massardo D R, Manna F, Schäfer B, Wolf K, Del Giudice L

Abstract excerpt

The petite-positive yeast Saccharomyces cerevisiae can be efficiently and completely converted to respiratory-deficient cytoplasmic petite mutants by intercalating drugs. Rho0 petites from Schizosaccharomyces pombe could only be obtained in strains carrying a nuclear mutation. In this paper we re...

Topics

Amaryllidaceae Alkaloids
DNA, Fungal
DNA, Mitochondrial
Drug Resistance, Microbial
Mutation
Phenanthridines
Schizosaccharomyces
Sequence Deletion

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