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Article

Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae.

Nucleic acids research - 15 Jul 2003

Rasmussen Anne Karin, Chatterjee Aditi, Rasmussen Lene Juel, Singh Keshav K

Abstract excerpt

Using Saccharomyces cerevisiae as a model organism, we analyzed the consequences of disrupting mitochondrial function on mutagenesis of the nuclear genome. We measured the frequency of canavanine-resistant colonies as a measure of nuclear mutator phenotype. Our data suggest that mitochondrial dysfunction leads to a nuclear mutator phenotype (i) when oxidative phosphorylation is blocked in wild-type yeast at...

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PMID: 12853606
DOI: 10.1093/nar/gkg446
PMCID: PMC165961

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REV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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