Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM).

Molecular human reproduction - 1 Nov 2002

Ferrand Pedro E, Fujimoto Toshio, Chennathukuzhi Vargheese, Parry Samuel, Macones George A, Sammel Mary, Kuivaniemi Helena, Romero Roberto, Strauss Jerome F

Abstract excerpt

Infection is believed to be a leading cause of preterm premature rupture of membranes (PPROM). The bacterial cell wall component, lipopolysaccharide (LPS), is thought to initiate tissue responses leading to PPROM in the setting of Gram negative infection. LPS is recognized by the innate immune system, including the proteins encoded by the CARD15 and TLR4 genes. A recently described mutation (2936insC) in CARD15...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Black People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Michigan

Share to Nod2 Signaling Adaptor Protein

Share to Pennsylvania

Share to Receptors, Cell Surface

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Identifiers

PMID: 12397216
DOI: 10.1093/molehr/8.11.1031

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM).PMID 12397216Read ↗

Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants.Semantic proximity Read ↗

159C>T CD14 genotype--functional effects on innate immune responses in term neonates.Semantic proximity Read ↗

Association of a maternal CD14 -159 gene polymorphism with preterm premature rupture of membranes and spontaneous preterm birth in multi-fetal pregnancies.Semantic proximity Read ↗

Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis.Semantic proximity Read ↗

Innate immune receptor genetic polymorphisms in pouchitis: is CARD15 a susceptibility factor?Semantic proximity Read ↗

A toll-like receptor 9 (rs352140) variant is associated with placental inflammation in newborn infants.Semantic proximity Read ↗

Clinical IRAK4 deficiency caused by homozygosity for the novel IRAK4 (c.1049delG, p.Gly350Glufs*15) variant.Semantic proximity Read ↗

Interactions among genes influencing bacterial recognition increase IBD risk in a population-based New Zealand cohort.Semantic proximity Read ↗

Importance of NOD2/CARD15 gene variants for susceptibility to and outcome of sepsis in Turkish children.Semantic proximity Read ↗

Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.Semantic proximity Read ↗

Toll-like receptor 2 polymorphism is associated with preterm birth.Semantic proximity Read ↗

A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.