Metabolic specialization associated with phenotypic switching in Candidaalbicans.

doi:10.1073/pnas.232566499

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Article

Metabolic specialization associated with phenotypic switching in Candidaalbicans.

Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002

Lan Chung-Yu, Newport George, Murillo Luis A, Jones Ted, Scherer Stewart, Davis Ronald W, Agabian Nina

Abstract excerpt

Phase and antigenic variation are mechanisms used by microbial pathogens to stochastically change their cell surface composition. A related property, referred to as phenotypic switching, has been described for some pathogenic fungi. This phenomenon is best studied in Candida albicans, where switch phenotypes vary in morphology, physiology, and pathogenicity in experimental models. In this study, we report an...

Topics

Base Sequence
Candida albicans
Cell Cycle
DNA Primers
Oligonucleotide Array Sequence Analysis
Phenotype
Polymerase Chain Reaction
RNA, Fungal
Reproducibility of Results

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Identifiers

PMID: 12397174
DOI: 10.1073/pnas.232566499
PMCID: PMC137518

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