Article
Expression of mutant Ets protein at the neuromuscular synapse causes alterations in morphology and gene expression.
EMBO reports - 1 Nov 2002
de Kerchove D'Exaerde Alban, Cartaud Jean, Ravel-Chapuis Aymeric, Seroz Thierry, Pasteau Fabien, Angus Lindsay M, Jasmin Bernard J, Changeux Jean-Pierre, Schaeffer Laurent
Abstract excerpt
The localized transcription of several muscle genes at the motor endplate is controlled by the Ets transcription factor GABP. To evaluate directly its contribution to the formation of the neuromuscular junction, we generated transgenic mice expressing a general Ets dominant-negative mutant specifically in skeletal muscle. Quantitative RT-PCR analysis demonstrated that the expression of genes containing an...
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