Article
Targeting of the ETS factor GABPalpha disrupts neuromuscular junction synaptic function.
Molecular and cellular biology - 1 May 2007
O'Leary Debra A, Noakes Peter G, Lavidis Nick A, Kola Ismail, Hertzog Paul J, Ristevski Sika
Abstract excerpt
The GA-binding protein (GABP) transcription factor has been shown in vitro to regulate the expression of the neuromuscular proteins utrophin, acetylcholine esterase, and acetylcholine receptor subunits delta and epsilon through the N-box promoter motif (5'-CCGGAA-3'), but its in vivo function remains unknown. A single point mutation within the N-box of the gene encoding the acetylcholine receptor epsilon subunit...
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