Article
Development of the neuromuscular junction: genetic analysis in mice.
Journal of physiology, Paris - 1 Jan 2000
Sanes J R, Apel E D, Burgess R W, Emerson R B, Feng G, Gautam M, Glass D, Grady R M, Krejci E, Lichtman J W, Lu J T, Massoulié J, Miner J H, Moscoso L M, Nguyen Q, Nichol M, Noakes P G, Patton B L, Son Y J, Yancopoulos G D, Zhou H
Abstract excerpt
Formation of the skeletal neuromuscular junction is a multi-step process that requires communication between the nerve and muscle. Studies in many laboratories have led to identification of factors that seem likely to mediate these interactions. 'Knock-out' mice have now been generated with mutations in several genes that encode candidate transsynaptic messengers and components of their effector mechanisms. Using...
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