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Article

The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction.

Neuron - 17 Jul 2003

McCabe Brian D, Marqués Guillermo, Haghighi A Pejmun, Fetter Richard D, Crotty M Lisa, Haerry Theodore E, Goodman Corey S, O'Connor Michael B

Abstract excerpt

We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a reduced NMJ synapse size, decreased neurotransmitter release, and aberrant presynaptic ultrastructure. These defects are similar to those we observe in mutants of BMP receptors and Smad transcription factors. However, whereas these BMP receptors and...

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PMID: 12873382
DOI: 10.1016/s0896-6273(03)00426-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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