Article
The evolutionarily conserved RNA binding protein SMOOTH is essential for maintaining normal muscle function.
Fly - 1 Jan 2000
Draper Isabelle, Tabaka Meg E, Jackson F Rob, Salomon Robert N, Kopin Alan S
Abstract excerpt
The Drosophila smooth gene encodes an RNA binding protein that has been well conserved through evolution. To investigate the pleiotropic functions mediated by the smooth gene, we have selected and characterized two sm mutants, which are viable as adults yet display robust phenotypes (including a significant decrease in lifespan). Utilizing these mutants, we have made the novel observation that disruption of the...
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