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Article

β-Catenin gain of function in muscles impairs neuromuscular junction formation.

Development (Cambridge, England) - 1 Jul 2012

Wu Haitao, Lu Yisheng, Barik Arnab, Joseph Anish, Taketo Makoto Mark, Xiong Wen-Cheng, Mei Lin

Abstract excerpt

Neuromuscular junction (NMJ) formation requires proper interaction between motoneurons and muscle cells. β-Catenin is required in muscle cells for NMJ formation. To understand underlying mechanisms, we investigated the effect of β-catenin gain of function (GOF) on NMJ development. In HSA-β-cat(flox(ex3)/+) mice, which express stable β-catenin specifically in muscles, motor nerve terminals became extensively...

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Identifiers

PMID: 22627288
DOI: 10.1242/dev.080705
PMCID: PMC3367446

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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