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Article

The zinc finger transcription factor ZBP-89 is a repressor of the human β2-integrin CD11b gene

15 Jan 2003

Abstract excerpt

Integrin CD11b is a differentiation marker of the myelomonocytic lineage and an important mediator of inflammation. Expression of the CD11b gene is transcriptionally induced as myeloid precursors differentiate into mature cells, then drops as monocytes further differentiate into macrophages. Previous studies have identified elements and factors involved in the transcriptional activation of the CD11b gene during...

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PMID: 12393719
DOI: 10.1182/blood-2002-03-0680

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