Article
Structural analysis of the CD11b gene and phylogenetic analysis of the alpha-integrin gene family demonstrate remarkable conservation of genomic organization and suggest early diversification during evolution.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1993
Fleming J C, Pahl H L, Gonzalez D A, Smith T F, Tenen D G
Abstract excerpt
CD11b is a member of the beta 2 subfamily of the human leukocyte integrins. Its expression is limited to mature myeloid and NK cells and is up-regulated during the course of granulocytic and monocytic differentiation. The CD11b/CD18 (Mo1) heterodimer promotes adhesion of granulocytes and monocyte...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Chromosome Mapping
- Conserved Sequence
- Drosophila
- Genetic Variation
- Humans
- Integrins
- Macrophage-1 Antigen
- Molecular Sequence Data
- Phylogeny
- Structure-Activity Relationship