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Article

β-arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling.

Communications biology - 18 Dec 2020

DeNies Maxwell S, Smrcka Alan V, Schnell Santiago, Liu Allen P

Abstract excerpt

It has become increasingly apparent that G protein-coupled receptor (GPCR) localization is a master regulator of cell signaling. However, the molecular mechanisms involved in this process are not well understood. To date, observations of intracellular GPCR activation can be organized into two categories: a dependence on OCT3 cationic channel-permeable ligands or the necessity of endocytic trafficking. Using CXC...

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Identifiers

PMID: 33339901
DOI: 10.1038/s42003-020-01510-2
PMCID: PMC7749148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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