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Article

Distinct patterns of B-cell receptor signaling in non-Hodgkin lymphomas identified by single-cell profiling

23 Dec 2016

Abstract excerpt

Kinases downstream of B-cell antigen receptor (BCR) represent attractive targets for therapy in non-Hodgkin lymphoma (NHL). As clinical responses vary, improved knowledge regarding activation and regulation of BCR signaling in individual patients is needed. Here, using phosphospecific flow cytometry to obtain malignant B-cell signaling profiles from 95 patients representing 4 types of NHL revealed a striking...

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PMID: 28011673
DOI: 10.1182/blood-2016-05-718494

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