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Article

The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles.

International immunology - 1 Apr 1997

Gosselin P, Lusignan Y, Brennan J, Takei F, Lemieux S

Abstract excerpt

A dual receptor system composed of activation and inhibitory receptors apparently controls NK cell-mediated lysis. In the C57BL/6 mouse, the NK1.1 molecule acts as an activation receptor whereas Ly-49A, C and G2 can inhibit NK cell lysis of target cells expressing specific MHC class I molecules....

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Alleles
Genetic Linkage
Killer Cells, Natural
Membrane Glycoproteins
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C3H

Mice, Inbred C57BL

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Identifiers

PMID: 9138013
DOI: 10.1093/intimm/9.4.533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-9138013-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles.PMID 9138013Read ↗

Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes.Semantic proximity Read ↗

Ly49A allelic variation and MHC class I specificity.Semantic proximity Read ↗

The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.Semantic proximity Read ↗

Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1.Semantic proximity Read ↗

Class I MHC-binding characteristics of the 129/J Ly49 repertoire.Semantic proximity Read ↗

H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer.Semantic proximity Read ↗

Ly49 receptors: evolution, genetic diversity, and impact on immunity.Semantic proximity Read ↗

Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.Semantic proximity Read ↗

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules.Semantic proximity Read ↗

An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire.Semantic proximity Read ↗

Independent control of Ly49g alleles: implications for NK cell repertoire selection and tumor cell killing.Semantic proximity Read ↗

Mapping of the BALB/c Ly49 cluster defines a minimal natural killer cell receptor gene repertoire.Semantic proximity Read ↗

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