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Article

The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998

Sundbäck J, Nakamura M C, Waldenström M, Niemi E C, Seaman W E, Ryan J C, Kärre K

Abstract excerpt

Mouse NK lymphocytes express Ly-49 receptors, which inhibit cytotoxicity upon ligation by specific MHC I molecules on targets. Different members of the lectin-like mouse Ly-49 receptor family recognize distinct subsets of murine H-2 molecules, but the molecular basis for the allelic specificity of Ly-49 has not been defined. We analyzed inhibition of natural killing by chimeric MHC I molecules in which the...

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PMID: 9637511

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.PMID 9637511Read ↗

Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.Semantic proximity Read ↗

Ligand interactions by activating and inhibitory Ly-49 receptors.Semantic proximity Read ↗

Ly49A allelic variation and MHC class I specificity.Semantic proximity Read ↗

The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand.Semantic proximity Read ↗

H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer.Semantic proximity Read ↗

The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles.Semantic proximity Read ↗

Reciprocal transfer of class I MHC allele specificity between activating Ly-49P and Ly-49W receptors by exchange of beta 4-beta 5 loop residues.Semantic proximity Read ↗

Independent control of Ly49g alleles: implications for NK cell repertoire selection and tumor cell killing.Semantic proximity Read ↗

An allele-specific, stochastic gene expression process controls the expression of multiple Ly49 family genes and generates a diverse, MHC-specific NK cell receptor repertoire.Semantic proximity Read ↗

Distinctive interactions at multiple site 2 subsites by allele-specific rat and mouse ly49 determine functional binding and class I MHC specificity.Semantic proximity Read ↗

Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from p53-deficient mice.Semantic proximity Read ↗

Expression of natural killer receptor alleles at different Ly49 loci occurs independently and is regulated by major histocompatibility complex class I molecules.Semantic proximity Read ↗

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