Article
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1998
Sundbäck J, Nakamura M C, Waldenström M, Niemi E C, Seaman W E, Ryan J C, Kärre K
Abstract excerpt
Mouse NK lymphocytes express Ly-49 receptors, which inhibit cytotoxicity upon ligation by specific MHC I molecules on targets. Different members of the lectin-like mouse Ly-49 receptor family recognize distinct subsets of murine H-2 molecules, but the molecular basis for the allelic specificity o...
Topics
- Alleles
- Animals
- Antigens, Ly
- Antigens, Surface
- Carrier Proteins
- Cytotoxicity, Immunologic
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Humans
- Killer Cells, Natural
- Lectins
- Lectins, C-Type
- Membrane Proteins
- Mice
- Mice, Inbred C57BL
- Rats
- Receptors, Immunologic
- Receptors, NK Cell Lectin-Like