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Article

Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability.

Journal of virology - 1 Nov 2002

Hill Melissa K, Shehu-Xhilaga Miranda, Crowe Suzanne M, Mak Johnson

Abstract excerpt

The full-length human immunodeficiency virus type 1 (HIV-1) mRNA encodes two precursor polyproteins, Gag and GagProPol. An infrequent ribosomal frameshifting event allows these proteins to be synthesized from the same mRNA in a predetermined ratio of 20 Gag proteins for each GagProPol. The RNA frameshift signal consists of a slippery sequence and a hairpin stem-loop whose thermodynamic stability has been shown in...

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Share to Dimerization
Share to Frameshifting, Ribosomal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to Leukocytes, Mononuclear

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Share to Protein Processing, Post-Translational

Share to RNA Stability

Source

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Identifiers

PMID: 12388684
DOI: 10.1128/jvi.76.22.11245-11253.2002
PMCID: PMC136739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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