Article
Proline residues within spacer peptide p1 are important for human immunodeficiency virus type 1 infectivity, protein processing, and genomic RNA dimer stability.
Journal of virology - 1 Nov 2002
Hill Melissa K, Shehu-Xhilaga Miranda, Crowe Suzanne M, Mak Johnson
Abstract excerpt
The full-length human immunodeficiency virus type 1 (HIV-1) mRNA encodes two precursor polyproteins, Gag and GagProPol. An infrequent ribosomal frameshifting event allows these proteins to be synthesized from the same mRNA in a predetermined ratio of 20 Gag proteins for each GagProPol. The RNA frameshift signal consists of a slippery sequence and a hairpin stem-loop whose thermodynamic stability has been shown in...
Topics
- Amino Acid Sequence
- Base Sequence
- Dimerization
- Frameshifting, Ribosomal
- Gene Products, gag
- Genome, Viral
- HIV Infections
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Peptides