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Article

Strategies for recognition of stem-loop RNA structures by synthetic ligands: application to the HIV-1 frameshift stimulatory sequence.

Journal of medicinal chemistry - 26 Aug 2010

Palde Prakash B, Ofori Leslie O, Gareiss Peter C, Lerea Jaclyn, Miller Benjamin L

Abstract excerpt

Production of the Gag-Pol polyprotein in human immunodeficiency virus (HIV) requires a -1 ribosomal frameshift, which is directed by a highly conserved RNA stem-loop. Building on our discovery of a set of disulfide-containing peptides that bind this RNA, we describe medicinal chemistry efforts designed to begin to understand the structure-activity relationships and RNA sequence-selectivity relationships...

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Identifiers

PMID: 20672840
DOI: 10.1021/jm100231t
PMCID: PMC2928052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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