Article
SV40 induced cellular immortalization: phenotypic changes associated with the loss of proliferative capacity in a conditionally immortalized cell line.
Oncogene - 1 Oct 1990
Mignotte B, Larcher J C, Zheng D Q, Esnault C, Coulaud D, Feunteun J
Abstract excerpt
Immortalization of rodent embryo fibroblasts by SV40 is dominantly maintained by the large T antigen. The aim of this work is to characterize some of the events associated with the loss of proliferative capacity in a rat cell line, called REtsAF, which is conditionally immortalized by the tsA58 a...
Topics
- Animals
- Bone Marrow Cells
- Cell Cycle
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Granulocyte-Macrophage Colony-Stimulating Factor
- Macrophage Colony-Stimulating Factor
- Macrophages
- Mice
- Mice, Inbred BALB C
- Microscopy, Electron
- Mitochondria
- Phenotype
- Simian virus 40
- Temperature
- Transfection