Article
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.
EMBO reports - 1 Mar 2005
Lechel André, Satyanarayana Ande, Ju Zhenyu, Plentz Ruben R, Schaetzlein Sonja, Rudolph Cornelia, Wilkens Ludwig, Wiemann Stephanie U, Saretzki Gabriele, Malek Nisar P, Manns Michael P, Buer Jan, Rudolph K Lenhard
Abstract excerpt
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect these cellular responses in mouse liver using the experimental system of TRF2 inhibition by a dominant-negative version of the protein (TRF2delta B delta M). We show that the level of telomere dysfunction correlates...
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