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Article

Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function.

American journal of physiology. Renal physiology - 1 Jul 2009

Wu Wei, Kitamura Shinji, Truong David M, Rieg Timo, Vallon Volker, Sakurai Hiroyuki, Bush Kevin T, Vera David R, Ross Robert S, Nigam Sanjay K

Abstract excerpt

Deletion of integrin-beta1 (Itgb1) in the kidney collecting system led to progressive renal dysfunction and polyuria. The defect in the concentrating ability of the kidney was concomitant with decreased medullary collecting duct expression of aquaporin-2 and arginine vasopressin receptor 2, while histological examination revealed hypoplastic renal medullary collecting ducts characterized by increased apoptosis,...

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Source

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Identifiers

PMID: 19439520
DOI: 10.1152/ajprenal.90260.2008
PMCID: PMC2711709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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