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Article

Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance.

Molecular biology of the cell - 1 Sept 2024

Nguyen Nga H, Sheng Shaohu, Banerjee Anupam, Guerriero Christopher J, Chen Jingxin, Wang Xueqi, Mackie Timothy D, Welling Paul A, Kleyman Thomas R, Bahar Ivet, Carlson Anne E, Brodsky Jeffrey L

Abstract excerpt

Hypertension affects one billion people worldwide and is the most common risk factor for cardiovascular disease, yet a comprehensive picture of its underlying genetic factors is incomplete. Amongst regulators of blood pressure is the renal outer medullary potassium (ROMK) channel. While select ROMK mutants are prone to premature degradation and lead to disease, heterozygous carriers of some of these same alleles...

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Identifiers

PMID: 39024255
DOI: 10.1091/mbc.E23-12-0494
PMCID: PMC11449386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance.PMID 39024255Read ↗

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