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Article

The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain.

The Journal of biological chemistry - 27 Dec 2002

Lan Zi-Jian, Chung Arthur C-K, Xu Xueping, DeMayo Francesco J, Cooney Austin J

Abstract excerpt

Germ cell nuclear factor (GCNF), an orphan nuclear receptor, is essential for mouse embryogenesis. GCNF specifically binds to a DR0 response element via its DNA binding domain (DBD) in vitro and functions as a repressor of gene transcription. To further study the role of GCNF during embryogenesis, we have employed a Cre/loxP strategy and generated a line of GCNF mutant mice (GCNF(lox/lox)) in which the 243-base...

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Identifiers

PMID: 12381721
DOI: 10.1074/jbc.M209586200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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