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Article

Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.

Developmental cell - 1 Jan 2004

Suzuki Takayuki, Takeuchi Jun, Koshiba-Takeuchi Kazuko, Ogura Toshihiko

Abstract excerpt

Despite extensive studies on the anterior-posterior (AP) axis formation of limb buds, mechanisms that specify digit identities along the AP axis remain obscure. Using the four-digit chick leg as a model, we report here that Tbx2 and Tbx3 specify the digit identities of digits IV and III, respectively. Misexpression of Tbx2 and Tbx3 induced posterior homeotic transformation of digit III to digit IV and digit II to...

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Source

Identifiers

PMID: 14723846
DOI: 10.1016/s1534-5807(03)00401-5

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.PMID 14723846Read ↗

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