Article
Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
The Journal of biological chemistry - 6 Sept 2002
Lee Hae-Wan, Ahn Dae-Ho, Crawley Suzanne C, Li Jian-Dong, Gum James R, Basbaum Carol B, Fan Nancy Q, Szymkowski David E, Han Sang-Young, Lee Bong H, Sleisenger Marvin H, Kim Young S
Abstract excerpt
MUC2 is a secretory mucin normally expressed by goblet cells of the intestinal epithelium. It is overexpressed in mucinous type colorectal cancers but down-regulated in colorectal adenocarcinoma. Phorbol 12-myristate 13-acetate (PMA) treatment of colon cancer cell lines increases MUC2 expression, so we have undertaken a detailed analysis of the effects of PMA on the promoter activity of the 5'-flanking region of...
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