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Article

High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

Topanurak Supachai, Ferraris Joan D, Li Jinxi, Izumi Yuichiro, Williams Chester K, Gucek Marjan, Wang Guanghui, Zhou Xiaoming, Burg Maurice B

Abstract excerpt

Glycerophosphocholine (GPC) is high in cells of the renal inner medulla where high interstitial NaCl and urea power concentration of the urine. GPC protects inner medullary cells against the perturbing effects of high NaCl and urea by stabilizing intracellular macromolecules. Degradation of GPC is catalyzed by the glycerophosphocholine phosphodiesterase activity of glycerophosphodiester phosphodiesterase domain...

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Identifiers

PMID: 23589856
DOI: 10.1073/pnas.1305220110
PMCID: PMC3645535

Genes

GDPD5
CDK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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