Article
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse.
Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002
Fradkin Lee G, Kamphorst Jessica T, DiAntonio Aaron, Goodman Corey S, Noordermeer Jasprina N
Abstract excerpt
Tetraspanins encode a large conserved family of proteins that span the membrane four times and are expressed in a variety of eukaryotic tissues. They are part of membrane complexes that are involved in such diverse processes as intracellular signaling, cellular motility, metastasis, and tumor suppression. The single fly tetraspanin characterized to date, late bloomer (lbm), is expressed on the axons, terminal...
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