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Article

Type 2 Diabetes-a Matter of ß-Cell Life and Death?

20 Jan 2005

Abstract excerpt

In type 2 diabetes, the beta cells of the pancreas fail to produce enough insulin to meet the body's demand, in part because of an acquired decrease in beta-cell mass. In adults, pancreatic beta-cell mass is controlled by several mechanisms, including beta-cell replication, neogenesis, hypertrophy, and survival. Here, I discuss evidence supporting the notion that increased beta-cell apoptosis is an important...

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Identifiers

PMID: 15662003
DOI: 10.1126/science.1104345

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