Article
Association of the F352V variant of the Klotho gene with bone mineral density.
Biogerontology - 1 Apr 2007
Riancho José A, Valero Carmen, Hernández José L, Ortiz Fernando, Zarrabeitia Ana, Alonso María A, Peña Nicolás, Pascual M Asunción, González-Macías Jesús, Zarrabeitia María T
Abstract excerpt
Klotho gene codes for a protein with glucuronidase activity and is thought to influence bone and vascular homeostasis. We studied the relationship of a common T/G polymorphism, resulting in a phenylalanine (F) to valine (V) substitution at aminoacid position 352, with bone mineral density (BMD) and osteoporotic fractures. The study group comprised 914 Spanish women, including 438 control subjects, 190 patients...
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