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Article

Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual.

The Journal of infectious diseases - 1 Mar 2009

Kim Arthur Y, Timm Joerg, Nolan Brian E, Reyor Laura L, Kane Katherine, Berical Andrew C, Zachary Kimon C, Lauer Georg M, Kuntzen Thomas, Allen Todd M

Abstract excerpt

The dramatic antiviral activities of drugs that specifically inhibit hepatitis C virus replication can be tempered by baseline mutations that confer resistance. We describe the kinetics of an R155K mutation in hepatitis C virus (HCV) NS3 protease known to confer resistance to specific protease inhibitors in an individual coinfected with human immunodeficiency virus-1 and HCV. Longitudinal sequences revealed...

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Share to Drug Resistance, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19199553
DOI: 10.1086/596657
PMCID: PMC2653266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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