Article
Antiretroviral resistance during successful therapy of HIV type 1 infection.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2000
Martinez-Picado J, DePasquale M P, Kartsonis N, Hanna G J, Wong J, Finzi D, Rosenberg E, Gunthard H F, Sutton L, Savara A, Petropoulos C J, Hellmann N, Walker B D, Richman D D, Siliciano R, D'Aquila R T
Abstract excerpt
HIV type 1 (HIV-1) drug resistance mutations were selected during antiretroviral therapy successfully suppressing plasma HIV-1 RNA to <50 copies/ml. New resistant mutant subpopulations were identified by clonal sequencing analyses of viruses cultured from blood cells. Drug susceptibility tests showed that biological clones of virus with the mutations acquired during successful therapy had increased resistance....
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