Article
In vivo emergence of drug-resistant mutations at less than 50 HIV-1 RNA copies/mL that are maintained at viral rebound in longitudinal plasma samples from human immunodeficiency virus type-1-infected patients on highly active antiretroviral therapy.
Journal of human virology - 1 Jan 2000
Elbeik T, Hoo B S, Campodonico M E, Dileanis J, Fay F F, Bortolozzi R L, Benetti M S, Fay O H, Marlowe N, Petrauskene O, Chernoff D, Smith L, Ng V L
Abstract excerpt
OBJECTIVE: Emergence of human immunodeficiency virus type-1 (HIV-1) genotypic drug resistance is generally attributed to noncompliance, poorly absorbed drugs, or drug-to-drug interaction. Attempts to determine emerging genotypic drug resistance from study subjects on highly active antiretroviral therapy (HAART) relied on insensitive polymerase chain reaction (PCR) techniques, revealing wild type HIV-1 or...
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