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Article

Fur-DNA interactions at the bidirectional fepDGC-entS promoter region in Escherichia coli.

Journal of molecular biology - 4 Oct 2002

Lavrrar Jennifer L, Christoffersen Catherine A, McIntosh Mark A

Abstract excerpt

The transcriptional repressor Fur binds to a 19-bp consensus sequence, 5'-GATAATGATAATCATTATC-3', under high iron conditions. The fepDGC-entS promoter of Escherichia coli contains two Fur-binding sites (FBS) offset by 6bp. Genetic studies of this promoter region revealed two mutations that exhibited a loss of iron regulation in vivo. One mutation altered the upstream portion of FBS 1, whereas the other,...

Topics

Bacterial Proteins
Base Sequence
DNA
DNA Footprinting
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Macromolecular Substances
Molecular Sequence Data
Mutation
Phenanthrolines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Repressor Proteins

Trans-Activators

Transcription, Genetic

Source

Identifiers

PMID: 12367523
DOI: 10.1016/s0022-2836(02)00849-5

Provenance

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