Article
Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice.
Neuroscience letters - 18 Feb 2011
Gu Huiying, Wei Xing, Monnot Andrew D, Fontanilla Christine V, Behl Mamta, Farlow Martin R, Zheng Wei, Du Yansheng
Abstract excerpt
Lead (Pb) is an environmental factor suspected of contributing to neurodegenerative diseases such as Alzheimer's disease (AD). In AD, it has been postulated that increased production and/or decreased metabolism/clearance of β-amyloid (Aβ) may lead to amyloid plaque deposition as well as a cascade of other neuropathological changes. It has been suggested that Pb exposure may be associated with AD-like pathology...
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