Article

Mutational analysis of the structure and function of the chaperone domain of UNC-45B

2020-01-03

Abstract excerpt

<h4>ABSTRACT</h4> UNC-45B is a multidomain molecular chaperone that is essential for the proper folding and assembly of myosin into muscle thick filaments in vivo . We have previously demonstrated that its UCS domain is responsible for the chaperone-like properties of UNC-45B. In order to better understand the chaperoning function of the UCS domain we engineered mutations designed to: i) disrupt chaperone-client...

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Literature Corpus work: e482f7b0-20fe-53e8-b19c-c40e0f609c2d
DOI: 10.1101/2020.01.03.894048

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