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Article

A key role for the alpha 1 helix of human RAP74 in the initiation and elongation of RNA chains.

The Journal of biological chemistry - 6 Dec 2002

Funk Janel D, Nedialkov Yuri A, Xu Dianpeng, Burton Zachary F

Abstract excerpt

RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II. Mutations within or adjacent to the alpha1 helix of the RAP74 subunit have been shown to decrease both initiation and elongation stimulation activities without strongly affecting the interactions of RAP74 with the...

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PMID: 12354769
DOI: 10.1074/jbc.M206249200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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