Article
Impact of gender and parent of origin on the phenotypic expression of hereditary nonpolyposis colorectal cancer in a large Newfoundland kindred with a common MSH2 mutation.
Diseases of the colon and rectum - 1 Sept 2002
Green Jane, O'Driscoll Mary, Barnes Adam, Maher Eamonn R, Bridge Peter, Shields Keith, Parfrey Patrick S
Abstract excerpt
PURPOSE: This study was designed to provide precise estimates of death and cancer risks, by gender and parent of origin, in hereditary nonpolyposis colorectal cancer independent of mutation, geographic variation, and ascertainment bias. METHODS: A group of 12 families with a founder MSH2 mutation (nucleotide 943+3, A --> T) causing hereditary nonpolyposis colorectal cancer was identified in Newfoundland. Genetic...
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