Article
The role of PGE(2) in the differentiation of dendritic cells: how do dendritic cells influence T-cell polarization and chemokine receptor expression?
Stem cells (Dayton, Ohio) - 1 Jan 2002
Lee Je-Jung, Takei Masao, Hori Shinichi, Inoue Yoshiko, Harada Yukie, Tanosaki Ryuji, Kanda Yoshinobu, Kami Masayuki, Makimoto Atsushi, Mineishi Shin, Kawai Hiroyuki, Shimosaka Akihiro, Heike Yuji, Ikarashi Yoshinori, Wakasugi Hiro, Takaue Yoichi, Hwang Tai-Ju, Kim Hyeoung-Joon, Kakizoe Tadao
Abstract excerpt
The role of prostaglandin E(2) (PGE(2)) in the function of dendritic cells (DCs), T-cell polarization, and expression of chemokine receptors was evaluated in human cells. Immature DCs were generated from peripheral blood CD14(+) cells using a combination of GM-CSF and interleukin-4 (IL-4) with or without PGE(2). On day 6, maturation of DCs was induced by the addition of tumor necrosis factor alpha with or without...
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