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Article

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

21 Oct 2008

Abstract excerpt

Hec1 (Highly Expressed in Cancer 1) is one of four proteins of the outer kinetochore Ndc80 complex involved in the dynamic interface between centromeres and spindle microtubules. Its overexpression is seen in a variety of human tumors and correlates with tumor grade and prognosis. We show here that the overexpression of Hec1 in an inducible mouse model results in mitotic checkpoint hyperactivation. As previously...

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PMID: 18940925
DOI: 10.1073/pnas.0803504105

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