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Article

Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?

Mutation research - 30 Sept 2002

Okochi Eriko, Watanabe Naoko, Sugimura Takashi, Ushijima Toshikazu

Abstract excerpt

Genetic instability plays important roles in carcinogenesis. In two cell lines which we established from mammary carcinomas induced in lacI-transgenic rats by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), spontaneous point mutation rates (MRs) of the endogenous hypoxanthine-guanine phosphoribosyltransferase (hprt) gene and lacI transgene were found to be increased. The two rat mammary carcinoma cell...

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Identifiers

PMID: 12351149
DOI: 10.1016/s0027-5107(02)00156-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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