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Article

Carcinogen-specific induction of genetic instability

10 Apr 2001

Abstract excerpt

It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have tested this hypothesis by treating immortal, genetically stable human cells with representative carcinogens. We found that cells resistant to the bulky-adduct-forming agent 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) exhibited a chromosomal...

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PMID: 11296254
DOI: 10.1073/pnas.081082898

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Source receipt: pubmed, retrieved 7 Sept 2026.

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