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Article

Protein stabilization by RSUME accounts for PTTG pituitary tumor abundance and oncogenicity

5 Apr 2018

Abstract excerpt

Increased levels of the proto-oncogene pituitary tumor-transforming gene 1 (PTTG) have been repeatedly reported in several human solid tumors, especially in endocrine-related tumors such as pituitary adenomas. Securin PTTG has a critical role in pituitary tumorigenesis. However, the cause of upregulation has not been found yet, despite analyses made at the gene, promoter and mRNA level that show that no...

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PMID: 29622689
DOI: 10.1530/erc-18-0028

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