Article
Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia.
Journal of perinatology : official journal of the California Perinatal Association - 1 Jan 2004
Manar Martha H, Brown Milton R, Gauthier Theresa W, Brown Lou Ann S
Abstract excerpt
OBJECTIVE: Reactive oxygen species (ROS) contribute to oxidative lung injury. The glutathione-S-transferases (GST) family and microsomal epoxide hydrolase (mEPHx) enzymes detoxify ROS, and genetic polymorphisms alter this detoxification. We hypothesized that polymorphisms encoding for less efficient enzymes were associated with bronchopulmonary dysphasia (BPD). STUDY DESIGN: We determined allelic distribution of...
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