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Article

The cleavage of the urokinase receptor regulates its multiple functions.

The Journal of biological chemistry - 6 Dec 2002

Montuori Nunzia, Carriero Maria Vincenza, Salzano Salvatore, Rossi Guido, Ragno Pia

Abstract excerpt

The urokinase-type plasminogen activator (uPA) is able to cleave its cell surface receptor (uPAR) anchored to the cell membrane through a glycophosphatidylinositol tail. The cleavage leads to the formation of cell surface truncated forms, devoid of the N-terminal domain 1 (D1) and unmasks or disrupts, depending on the cleavage site, a sequence in the D1-D2 linker region (residues 88-92), which in the soluble form...

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Identifiers

PMID: 12297505
DOI: 10.1074/jbc.M207494200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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