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Article

Domain Interplay in the Urokinase Receptor

1 Sept 1996

Abstract excerpt

The urokinase plasminogen activator receptor (uPAR) is a membrane protein comprised of three extracellular domains. In order to study the importance of this domain organization in the ligand-binding process of the receptor we subjected a recombinant, soluble uPAR (suPAR) to specific proteolytic cleavages leading to liberation of single domains. Treatment of the receptor with pepsin resulted in cleavage between...

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PMID: 8798468
DOI: 10.1074/jbc.271.37.22885

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