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Article

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.

Cell - 20 Sept 2002

Garrett Thomas P J, McKern Neil M, Lou Meizhen, Elleman Thomas C, Adams Timothy E, Lovrecz George O, Zhu Hong-Jian, Walker Francesca, Frenkel Morry J, Hoyne Peter A, Jorissen Robert N, Nice Edouard C, Burgess Antony W, Ward Colin W

Abstract excerpt

We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts with both L1 and L2 domains of EGFR, making many main chain contacts with L1 and interacting with L2 via key conserved residues. The results indicate how EGFR family members can bind a family of highly variable ligands. In the 2:2 TGFalpha:sEGFR501 complex, each ligand interacts with...

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Identifiers

PMID: 12297049
DOI: 10.1016/s0092-8674(02)00940-6

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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