Article
[Determination of acetylation phenotype in the therapeutic monitoring of drugs].
Klinicheskaia laboratornaia diagnostika - 1 Jan 2000
Evgen'ev M I, Garmonov S Iu, Pogorel'tsev V I, Kurtbelialova Kh I, Valimukhametova D A
Abstract excerpt
New methods for detecting the acetylation phenotype have been developed for therapeutic monitoring using isoniazid as the pharmacogenetic marker. The study is carried out with 4-chloro-5,7-dinitrobenzofurane by direct spectrophotometry, high performance liquid and thin-layer chromatography. The methods proved to be highly sensitive, selectively detecting isoniazid, simple, and requiring no sophisticated...
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