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Article

Heavy metals modulate the activity of the purinergic P2X4 receptor.

Toxicology and applied pharmacology - 15 Jan 2005

Coddou Claudio, Lorca Ramón A, Acuña-Castillo Claudio, Grauso Marta, Rassendren Francois, Huidobro-Toro J Pablo

Abstract excerpt

To further characterize the nature of the regulatory metal-binding sites of the rat P2X(4) receptor, several transition heavy metals were tested to examine their ability to mimic the facilitator action of zinc or the inhibitory action of copper. cDNA coding for the rat P2X(4) receptor was injected into Xenopus laevis oocytes; the two-electrode voltage-clamp technique was used to measure and quantify the...

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Source

Identifiers

PMID: 15629187
DOI: 10.1016/j.taap.2004.06.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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